Livedoid vasculitis - Livedoidinis Vaskulitas
Livedoidinis Vaskulitas (Livedoid vasculitis) yra lėtinė odos liga, dažniausiai pasireiškianti jaunoms ir vidutinio amžiaus moterims. Vienas akronimas, naudojamas apibūdinti šios ligos ypatybes, yra „Skausmingos purpurinės opos su tinkliniu apatinių galūnių raštu“ (PURPURINĖ). Ši liga susijusi su daugybe kitų sutrikimų, įskaitant lėtinę veninę hipertenziją ir venų varikozę.
☆ 2022 m. Stiftung Warentest iš Vokietijos rezultatai rodo, kad vartotojų pasitenkinimas ModelDerm buvo tik šiek tiek mažesnis nei mokamų nuotolinės medicinos konsultacijų.
Jį gali lydėti skausmas.
relevance score : -100.0%
ReferencesLivedoid vasculopathy yra reta odos liga, kuriai būdingos skausmingos opos, nuolat atsirandančios ant blauzdų.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy yra reta odos liga, sukelianti pasikartojančias opas ant blauzdų, palikusius blyškius randus, vadinamus atrofija. Nors tiksli priežastis vis dar neaiški, manoma, kad padidėjęs kraujo krešėjimas (hypercoagulability) yra pagrindinis veiksnys, o uždegimas vaidina antraeilią rolę. Veiksniai, prisidedantys prie krešėjimo, yra šie: baltymų C ir S trūkumai (deficiencies in proteins C and S), genetinės mutacijos, tokios kaip faktorius V Leiden (factor V Leiden), antitrombino III trūkumas (antithrombin III deficiency), prothrombino geno mutacijos (prothrombin gene mutations), padidėję homocisteino lygiai (high levels of homocysteine). Biopsijose matoma kraujo krešulių buvimas kraujagyslių viduje, kraujagyslių sienelių sustorėjimas ir randai. Gydymas apima daugialypį metodą, sutelkiant dėmesį į kraujo krešulių prevenciją vaistais, tokiais kaip antitrombocitiniai vaistai, kraujo skiedikliai ir fibrinolizinis gydymas. Šiai odos būklei gydyti gali būti naudojami įvairūs vaistai – kolchicinas (colchicine) ir hidroksiklorochinas (hydroxychloroquine), vazodilatatoriai (vasodilators), imunosupresantai (immunosuppressants).
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy yra reta būklė, kai pažeidžiamos abi kojos. Manoma, kad kraujo krešulių susidarymą mažose kraujagyslėse sukelia padidėjęs krešėjimas, sumažėjęs krešulių įsisavinimas ir kraujagyslių gleivinės pažeidimas. Tai dažniau pasitaiko moterims, ypač nuo 15 iki 50 metų. Nustoti rūkyti, rūpintis žaizdomis ir vartoti vaistus, pvz. kraują skystinančius ir antitrombocitinius, buvo veiksminga.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
